Prostacyclin-dependent Apoptosis Mediated by PPARδ
نویسندگان
چکیده
منابع مشابه
Prostacyclin-dependent Apoptosis Mediated by PPAR
Prostacyclin (PGI2) plays important roles in hemostasis both as a vasodilator and an endogenous inhibitor of platelet aggregation. PGI2 functions in these roles through a specific IP receptor, a G protein-coupled receptor linked to Gs and increases in cAMP. Here, we report that intracellular prostacyclin formed by expressing prostacyclin synthase in human embryonic kidney 293 cells promotes apo...
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To study the protective effect of prostacyclin (PGI2) we increased PGI2 production by infected NRK-52E cells with an adenovirus carrying cyclooxygenase-1 and prostacyclin synthase. PGI2 overexpression protected these cells from gentamicin-induced apoptosis by reducing cleaved caspase-3 and caspase-9, cytochrome c, and decreasing generation of reactive oxygen species. Expression of the nuclear r...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m107180200